The declaration by the World Health Organization (WHO) that the COVID-19 pandemic is no longer a Public Health Emergency of International Concern brings a sense of relief but should not be a cause for complacency. While epidemics eventually wane or transform into seasonal outbreaks, the threat of COVID-19 remains. The emergence of multiple variants and subvariants, along with the absence of a predictable seasonal pattern, means that the virus can still cause rapid transmission, severe disease, hospitalizations, and even higher mortality rates. Eternal vigilance is crucial to prevent the world from slipping into complacency. To maintain a level of care and readiness, health systems need to remain vigilant and periodically test their capacity to respond to epidemic situations. The established network of genetic sequencing laboratories and the healthcare infrastructure developed during the pandemic should continue to be utilized effectively. Additionally, research and development efforts should not be scaled back. Continued investment in vaccine platforms, drug delivery systems, antivirals, and antibiotics will enable nations to be prepared not only for COVID-19 but also for other emerging infections that may arise in the future. At the individual level, it is important to maintain personal hygiene practices and adhere to vaccination schedules. Following hand hygiene and wearing masks when necessary can help reduce the risk of transmission. These habits that have become ingrained during the pandemic should continue to be practiced to protect oneself and others. The WHO’s announcement marks an important milestone in the fight against COVID-19, but it is not a signal that the battle is over. Remaining cautious, vigilant, and prepared is necessary to navigate the ongoing challenges posed by the virus. By staying proactive and continuing to prioritize public health measures, both at the institutional and individual level, we can mitigate the impact of the virus and be better equipped to respond to future health crises.